Pathophysiological mechanisms in antiphospholipid syndrome
نویسندگان
چکیده
منابع مشابه
Pathophysiological mechanisms in antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by recurrent thrombosis and fetal loss in the presence of persistently positive antiphospholipid (aPL) antibodies (Abs) including lupus anticoagulant (LAC), IgG/IgM anticardiolipin (aCL) Abs and anti-b2glycoprotein I (b 2 GPI) Abs [1–3]. aPL Abs are a heterogenous group of autoantibodies that react to phospholipids (...
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The antiphospholipid syndrome (APS) is characterized by venous and/or arterial thrombosis and severe pregnancy morbidity in presence of antiphospholipid antibodies (aPL). While there is compelling evidence that aPL cause the clinical manifestations of APS, the underlying mechanisms are still a matter of scientific debate. This is mainly related to the broad heterogeneity of aPL. There are three...
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ژورنال
عنوان ژورنال: International Journal of Clinical Rheumatology
سال: 2011
ISSN: 1758-4272
DOI: 10.2217/ijr.11.9